It's the final page from "Pugs: God's Little Weirdos", and the original art is now available for someone with an undying love for all things "pug".
It's drawn with archival, lightfast inks on acid-free Bristol Vellum cardstock...and just like a pug, this original is guaranteed to make you feel like life is pretty awesome. It features Sheldon and Oso in their big "reunion" shot, after Oso had been lost for days going on his accidental adventures.
Here's a close-up shot of the two:
[And if you'd like to see a larger, clearer version of the image, click here.